Synthesis of the C1-C21 (C1'-C21') fragment of the dimeric polyketide natural product SCH 351448.
نویسندگان
چکیده
[structure: see text] A convergent, stereoselective assembly of the C1-C21 (C1'-C21') fragment of SCH 351448, a 28-membered bis-lactone natural product, has been developed. A highly efficient approach to this fragment assembles 75% of the carbon skeleton and all the stereochemical elements present in the natural product. In addition, an interesting boron ligand effect on the diastereoselectivity of a key aldol reaction with methyl ketone-derived enolborinates is reported.
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ورودعنوان ژورنال:
- Organic letters
دوره 4 4 شماره
صفحات -
تاریخ انتشار 2002